Oct 2023 | Perelman School of Medicine | Cell

New study by US researchers from the Perelman School of Medicine investigates the link between serotonin deficiency and long COVID

A recent study by the Perelman School of Medicine, published in the journal Cell in October 2023, indicates that a deficiency of the hormone serotonin could contribute to the development of long-COVID symptoms and influence their course. Serotonin is a messenger substance that influences the immune system, the nervous system and the inflammatory response, among other things. 

The study found that people with Long COVID had lower serotonin levels compared to recovered persons. The reduced serotonin level could therefore possibly be involved in the development of Long COVID symptoms and lead to impaired brain function and nervous system. Altered blood clotting could also be a consequence of the reduced serotonin level - this can lead to small blood clots ("microthrombi"), which are being discussed as a cause of Long COVID.  


Perelman School of Medicine

The Perelman School of Medicine at the University of Pennsylvania is the oldest medical school in the USA and is one of the most prestigious universities in the country. In 2023, professors Katalin Karikó and Drew Weissmann, who conduct research at the university, were awarded the Nobel Prize in Medicine for their research on mRNA vaccines. 


Cell is a renowned scientific journal. The articles published are subject to special peer review. Cell primarily publishes articles on current research topics in the field of experimental cell biology.